Man who let deadly snakes bite him 200+ times could be key to new antivenom


Scientists have developed a groundbreaking broad-spectrum antivenom using antibodies from a man in Wisconsin, Tim Friede, who endured over 200 venomous snake bites (and hundreds more self-injections) over nearly two decades unco.edu+15smithsonianmag.com+15washingtonpost.com+15. From species such as king cobras, black mambas, and rattlesnakes, this extreme exposure triggered his immune system to produce rare, broadly reactive antibodies.

Researchers at Columbia University (led by Peter Kwong) and Centivax (with Jacob Glanville) isolated two of these potent antibodies. When combined with the drug varespladib, the cocktail successfully protected mice against venom from 19 highly dangerous snakes, fully neutralizing 13 species and partially neutralizing the remaining six cen.acs.org+10nature.com+10wsj.com+10.

This represents a potential leap forward from today's antivenoms, which are typically species-specific, costly, and often made with animal antibodies—raising risks of allergic reactions and limited cross-species protection the-sun.com+8cuimc.columbia.edu+8wsj.com+8. A universal treatment would greatly benefit the 110,000+ people killed annually and hundreds of thousands more permanently disabled by snakebites youtube.com+15cuimc.columbia.edu+15nypost.com+15.

Next steps include expanded animal testing—veterinary trials in Australia are planned—and eventual human clinical trials within the next few years washingtonpost.com. However, ethical questions linger, given Tim’s self-experimentation and the largely experimental status of human-derived antibodies wsj.com+1the-sun.com+1.

This innovation, grounded in one individual’s extraordinary immunity, offers a promising pathway toward safer, more versatile antivenoms that could revolutionize global snakebite treatment.

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