New Study Confirms that Cancer Cells Ferment Glutamine


Over the past seven years, the Seyfried Lab at Boston College has conducted extensive research to determine the primary energy sources that cancer cells utilize for growth and survival. In December 2024, their findings were published in the journal ASN Neuro, providing new insights into cancer metabolism.​

The study revealed that cancer cells predominantly rely on two fermentable fuels: glucose and glutamine. While the role of glucose in cancer cell metabolism has been well-documented, this research highlighted glutamine fermentation as a significant contributor to ATP production in cancer cells. This challenges the traditional view that oxidative phosphorylation is the main energy source for these cells.

To explore therapeutic implications, the researchers combined a calorie-restricted ketogenic diet with a glutamine antagonist known as DON (6-diazo-5-oxo-L-norleucine) in mouse models of glioblastoma. This combination aimed to simultaneously restrict both glucose and glutamine availability to tumor cells. The results demonstrated that this dual-targeting approach effectively reduced tumor growth, improved survival rates, and minimized side effects compared to conventional treatments.

These findings support the metabolic theory of cancer, which posits that cancer's origin lies in mitochondrial dysfunction leading to altered energy metabolism, rather than solely in genetic mutations. By targeting the specific metabolic dependencies of cancer cells, such as their reliance on glucose and glutamine fermentation, new therapeutic strategies may be developed to more effectively combat tumor growth.​

Sources:

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